Lamisil tablets (terbinafine)

Lamisil (terbinafine) is the most effective and also worldwide most popular antifungal medication

What is Lamisil

Main information

Lamisil spray Lamisil (generic name: terbinafine) is antifungal drug for general use available as tablets, cream, spray and oinment.

Mechanism of action

The active substance is terbinafine, a derivative of allylamine antifungals. Effective against many species of dermatophytes, molds, and yeasts and some other pathogenic fungi. Action of terbinafine, as antifungal drug from the group of imidazole and triazole derivatives, leads to inhibition of the synthesis of ergosterol, an essential component of the fungal cell membrane. The cell membrane is damaged, the consequence is the death of fungal cells. After oral terbinafine is deposited in the skin (especially the stratum corneum), hair (also isolated from tallow reaching high concentration in the hair follicles) and nails, to yield fungicidal concentration.

Indication

The drug is indicated for the treatment of fungal infections caused by dermatophytes such as:

  • onychomycosis
  • scalp ringworm
  • ringworm of the skin including the torso, groin, foot
  • skin infections caused by yeasts

Dosing and Administration

How to take Lamisil

The drug is in the form of tablets and is intended for oral use. Use the product in accordance with the recommendations of the doctor. Do not exceed the recommended doses because it does not increase the effectiveness of the drug and may harm Your health and life. If you have any doubts regarding the use of the drug, consult your doctor. In certain specific groups of patients, it is necessary to further modification of the dosage.

Adults 250 mg 1 time a day. The duration of treatment depends on the indication and the severity of the infection, interdigital tinea pedis, the type of plantar (moccasin) 2-6 weeks, athlete's torso, groin itch obrębna 2-4 weeks, 2-4 weeks of skin candidiasis, ringworm of the scalp 4 weeks, onychomycosis usually 6-12 weeks (hands - 6 weeks, feet - 12 weeks, sometimes longer).

Children up to 2 years of age:

Use in children:

Normally used in children with a body weight of less than 20 kg: 62,5 mg (1/2 tabl. 125 mg) once a day; in children with a body weight 20-40 kg: 125 mg 1 time per day; in children with a body weight of more than 40 kg: 250 mg 1 time per day.

Due to the lack of data, Lamisil should not be used in children under 2. years of age.

Side Effects

Full list of possible side effects

Very often:

  • feeling of fullness, loss of appetite, indigestion, nausea, abdominal pain of low volume, diarrhea, mild skin reactions (rash, urticaria), pain in the joints or muscles. Common: headache. Uncommon: taste disturbance, ageusia, decreased appetite.

Rare

  • disorders of liver function and bile ducts (bile retention). Very rare: dizziness, sensory disturbances (paresthesia, hypoesthesia), haematological disorders (neutropenia, agranulocytosis, thrombocytopenia), severe liver failure, rzekomoanafilaktyczne reactions including swelling of vascular Cutaneous Lupus Erythematosus, motor and SLE, severe skin reactions (Eg, Stevens-Johnson syndrome, toxic epidermal necrolysis, acute generalized pustular rash), psoriasiform eruptions, exacerbation of psoriasis, alopecia, fatigue.
  • Urticaria
  • Swelling of the face and tongue

In the case of a massive invasion and intensive worms excretion is observed lasting abdominal pain and diarrhea. Rarely, hypersensitivity reactions, skin redness, hives and angioedema.

Contraindications

Contraindications and precautions

Unfortunately, even if there are indications for use of the drug, you can not always use it. You can not use the product if you are allergic (hypersensitivity) to any component of the formulation. This product is not intended to be used in the treatment of pityriasis versicolor.

The drug should not be used during pregnancy unless your doctor considers it necessary, and in its assessment of the expected benefits to the mother outweigh the potential risk to the fetus. Only a doctor can assess the benefit/risk ratio in your case.

Buy Lamisil online

Online pharmacies where you can order Lamisil or its generic vesion terbinafine online

Additional information

Take caution when using Lamisil

Lamisil Tablets

Some diseases and other circumstances may contraindicate to apply or the indication to change the dosing preparation. In certain situations it may be necessary to carry out certain checks.

It is not recommended to apply the drug in individuals with chronic or acute liver disease. Liver disease can cause a significant reduction in the excretion of the drug which could prolong its action and intensify them. If you ever were in your liver dysfunction or disease of the liver, you should consult your doctor before using the drug.

In some people, especially in patients with severe underlying diseases may be associated with the use of an action hepatotoksycznego (toxic action on the liver). Very rarely observed severe liver failure, leading to death or requiring liver transplant.

Usually before the treatment and in the doctor will recommend regular testing parameters which characterise the liver. These studies are necessary if the treatment takes longer than 6 weeks. If there are any symptoms that may suggest a disturbance, liver Such as: persistent nausea and vomiting, fatigue, faintness, dark color urine, clear his foot, jaundice, lethargy, consult a doctor immediately as it may be, since no longer since it may be necessary to discontinue the use of the drug.

Very rarely, the use of the drug may be associated with onset of severe hypersensitivity reaction type systemic anaphylaxis or severe skin changes, such as the Stevens and Johnson, necrosis toxic rozpływna epidermis. If there is a cumulative a rash, you should discontinue the use of the drug and immediately consult a doctor.

Very rarely during treatment may occur hematological disorders, such as anemia, thrombocytopenia, reducing the number of cytoplasmic antibodies or cytoplasmic all kinds. If there are any irregularities in the composition blood, consult a physician. Doctor will assess whether it is desirable to continue use of the drug.

In case of sore throat or fever, consult a doctor who will recommend the image control. It is not recommended to apply the drug in individuals with impaired renal function, if the creatinine clearance is less than 50 ml/min.

Attention should be paid to the fact that terbinafine may interact with other drugs used in parallel. Therefore, in the case of parallel use of certain drugs (cf. paragraph can I apply in parallel to other drugs?) it is necessary to keep under close supervision of a doctor. Additional information about the other ingredients: drug in the form of tablets 125 mg contains lactose; people from Galactose intolerance, lactase deficiency or glucose-Galactose malabsorption is, should not use this drug.

There has been research into the effects of drug on the ability to drive vehicles and handling equipment/machinery. People, in which they occur dizziness should not lead vehicles or operate mechanical devices/machines.

Precautions

It is not necessary to modify the dosage in the elderly, unless there are abnormalities of liver or kidney.

Not recommended for use in patients with chronic or acute liver disease.

It is not recommended to apply the preparation in individuals with impaired renal function, if the creatinine clearance is less than 50 ml/min.

Lamisil Cream